化学
细胞毒性T细胞
绝对构型
黄烷酮
立体化学
Wnt信号通路
预酸化
圆二色性
癌细胞系
细胞培养
信号转导
癌细胞
癌症
生物化学
生物
类黄酮
酶
体外
抗氧化剂
遗传学
作者
Motahare Boozari,Samad Nejad Ebrahimi,Saeid Soltani,Zahra Tayarani‐Najaran,Seyed Ahmad Emami,Javad Asili,Mehrdad Iranshahi
标识
DOI:10.1016/j.bioorg.2019.01.051
摘要
A new prenylated flavonostilbene, namely, alopecurone P together with three known compounds sophoraflavanone G, 2-(4-hydroxyphenyl)-2,3-dihydrobenzo[b]furan-3,4,6-triol and alopecurone J were characterized from the roots of Sophora pachycarpa. The absolute configuration of alopecurones J and P were characterized by comparison of experimental electronic circular dichroism (ECD) spectroscopy and simulated data using time-dependent density functional theory (TDDFT) for possible stereoisomers. The cytotoxic properties of isolated compounds have also been evaluated on two breast cancer cell lines (MCF-7 and MDA-MB-231) and normal cell line (NIH/3T3) using AlamarBlue®, flowcytometry and western blot assays. Alopecurone J and P showed cytotoxic effect on MCF-7 cell line through Wnt signaling pathway. It seems that the presence of lavandulyl substitution in C-8 position of flavanone structure increased the cytotoxic effect.
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