平滑
维莫德吉
刺猬信号通路
刺猬
信号转导
药理学
生物
癌症研究
医学
生物信息学
细胞生物学
作者
Heng Zhang,Zhi‐Jun Sun,Zhao‐Peng Liu,Chunxia Song
出处
期刊:Future Medicinal Chemistry
[Newlands Press Ltd]
日期:2018-12-01
卷期号:10 (24): 2855-2875
被引量:19
标识
DOI:10.4155/fmc-2018-0200
摘要
Hedgehog (HH) signaling pathway plays vital roles in controlling embryonic cell fate and homeostatic, and becomes dormant in mature individuals, aberrant activation of HH signaling pathway is involved in a number of human cancers. Smoothened (SMO), a vital transducer of HH signaling pathway, attracts significant attentions in HH signaling pathway-related cancer therapy. The approval of SMO antagonists vismodegib proves that SMO is a promising therapeutic target, and a number of SMO antagonists are reported since then. However, high incidence of tumor recurrence with the clinical application of vismodegib urges exploring of novel drugs with antiresistance profiles. This review provides an overview of SMO mutations reported in the literature, crystal structures of SMO, as well as reported antagonists with antiresistance profiles.
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