神经炎症
下调和上调
星形胶质细胞
PI3K/AKT/mTOR通路
小胶质细胞
蛋白激酶B
细胞生物学
肿瘤坏死因子α
神经退行性变
NF-κB
白细胞介素6
化学
神经科学
癌症研究
信号转导
生物
炎症
免疫学
医学
内科学
疾病
生物化学
中枢神经系统
基因
作者
Xiequn Xu,Aiwu Zhang,Yingting Zhu,Wen He,Wei Di,Fang Yu,Xiaolei Shi
摘要
Recent evidence have suggested that neuroinflammation and ischemia induce the activation of two different types of reactive astrocytes, termed A1 and A2. Additionally, A1 astrocytes contribute to the death of neurons and oligodendrocytes in neurodegenerative diseases, such as Alzheimer's disease (AD). In the current study, we constructed an Aβ42-activated microglia-conditioned medium to induce A1 astrocytic activation via secretion of interleukin 1α, tumor necrosis factor, and complement component 1q in vitro, and indicated the regulatory role of milk fat globule epidermal growth factor 8 (MFG-E8) on A1/A2 astrocytic alteration through the downregulation of nuclear factor-κB and the upregulation of PI3K-Akt. This study showed that MFG-E8 suppressed A1 astrocytes and holds great potential for the treatment of AD.
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