烟酰胺腺嘌呤二核苷酸
烟酰胺
化学
烟酰胺腺嘌呤二核苷酸磷酸
电极
辅因子
氧化铟锡
还原酶
氧化还原
酶
NAD+激酶
无机化学
生物化学
物理化学
氧化酶试验
作者
Clare F. Megarity,Bhavin Siritanaratkul,Rachel S. Heath,Lei Wan,Giorgio Morello,Sarah R. FitzPatrick,Rosalind L. Booth,Adam J. Sills,Alexander W. Robertson,Jamie H. Warner,Nicholas J. Turner,Fräser A. Armstrong
标识
DOI:10.1002/anie.201814370
摘要
Abstract In living cells, redox chains rely on nanoconfinement using tiny enclosures, such as the mitochondrial matrix or chloroplast stroma, to concentrate enzymes and limit distances that nicotinamide cofactors and other metabolites must diffuse. In a chemical analogue exploiting this principle, nicotinamide adenine dinucleotide phosphate (NADPH) and NADP + are cycled rapidly between ferredoxin–NADP + reductase and a second enzyme—the pairs being juxtaposed within the 5–100 nm scale pores of an indium tin oxide electrode. The resulting electrode material, denoted (FNR+E2)@ITO/support, can drive and exploit a potentially large number of enzyme‐catalysed reactions.
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