Desymmetrization of cyclohexadienones via D-camphor-derived triazolium salt catalyzed intramolecular Stetter reaction

Enantioselective desymmetrization of cyclohexadienones via a D-camphor-derived triazolium salt catalyzed intramolecular Stetter reaction was realized. With 10 mol% of camphor-derived triazolium salt E and 10 mol% of DIEA, various substituted cyclohexadienones proceeded through an intramolecular Stetter reaction, affording tricyclic products in moderate to good yields and excellent ee.