Synthesis of two impurities of salbutamol

To improve the quality control of salbutamol,two related substances were synthesized.Starting from 4-hydroxy-acetophenone and 4-hydroxy-3-methyl-acetophenone,a convenient synthetic route was designed including bromination,subsititution using N-(tert-butyl)benzylamine,deprotection of benzyl group,and reduction with NaBH4.The raw materials were cheap and easy to obtain and the reaction conditions were mild.The structures of the target compouds were verified by 1H-NMR and MS.The target compounds can be used as the reference substance of the related substances in the quality control of salbutamol.