高尿酸血症
黄嘌呤氧化酶
芹菜素
乙胺丁醇
尿酸
化学
药理学
嘌呤
体内
槲皮素
生物化学
医学
类黄酮
抗氧化剂
酶
抗生素
生物
链霉素
生物技术
出处
期刊:Modern Preventive Medicine
日期:2012-01-01
被引量:1
摘要
OBJECTIVE To study the effect and mechanism of the same doses of Quercetin(Que)and Apigenin(Api)on hyperuricemic rats which were lavaged by adenine and ethambutol hydrochloride. METHODS SD rats with hyperuricemia were induced by adenine and ethambutol hydrochloride intragastrically,and then given Que and Api for 3 weeks. The Serum Uric Acid(SUA)and the activity of serum and liver Xanthine Oxidase(XOD),adenosine deaminase(ADA)were observed. RESULTS Que and Api could effectively reduce SUA,and the activity of ADA in the serum and liver of hyperuricemic rats. Que could effectively inhibited the activity of xanthine oxidase(XOD)in liver,but Api had little effect on XOD. CONCLUSION Que and Api could interfere adenine and ethambutol hydrochloride induced hyperuricemia in rats. The possible mechanism is that Que through inhibiting the activity of XOD and ADA,reduce the amount of uric acid formation,thereby through inhibiting the activity of XOD and ADA,reduce the amount of uric acid formation,thereby reducing the level of serum uric acid;and apigenin may inhibit the activity of ADA in vivo,perhaps there are other ways to reduce the level of SUA,but the specific mechanism needs further study.
科研通智能强力驱动
Strongly Powered by AbleSci AI