已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Immediate Effects of Positive End-Expiratory Pressure and Low and High Tidal Volume Ventilation upon Gas Exchange and Compliance in Patients with Acute Lung Injury

潮气量 呼气末正压 医学 肺顺应性 麻醉 通风(建筑) 机械通风 高原压力 充氧 顺从(心理学) 肺容积 呼吸分钟容积 呼吸系统 内科学 物理 机械工程 社会心理学 心理学 工程类 热力学
作者
Darren Burns,T. Aaron West,Kenneth Hawkins,Grant E. O'Keefe
出处
期刊:Journal of Trauma-injury Infection and Critical Care [Lippincott Williams & Wilkins]
卷期号:51 (6): 1177-1181 被引量:3
标识
DOI:10.1097/00005373-200112000-00026
摘要

Protective ventilation, in general, includes low tidal volume ventilation and maintaining end-inspiratory plateau pressures less than 35 cmH2O. Recent clinical studies have determined that such an approach results in improved survival in patients with moderate to severe acute lung injury and acute respiratory distress syndrome. However, experimental evidence suggests that repeated end-expiratory collapse and reexpansion contributes to ventilator-induced lung injury. We sought to determine the immediate effects of specific tidal volume-PEEP combinations upon oxygenation and static compliance in patients with moderate to severe acute lung injury.Fourteen patients were prospectively studied and were treated with each of 10 tidal volume-PEEP combinations, applied in random order. After 5 minutes at each tidal volume-PEEP combination, PaO2/FIO2 and static compliance were recorded. Comparisons were made between low and high tidal volume ventilation as well as across five PEEP levels.At both low (6 mL/kg) and high (10 mL/kg) tidal volume ventilation, PaO2/FIO2 increased with increasing PEEP, up to 20 cmH2O. Similar changes in static compliance were not evident. Static compliance was highest at PEEP of 10 and 15 cmH2O, regardless of tidal volume. With PEEP set at 5 cmH2O, static compliance was significantly lower with 6 mL/kg than with 10 mL/kg tidal volumes. Overall, static compliance was lowest for both tidal volume conditions with PEEP set at 25 cmH2O.Low tidal volume ventilation with PEEP set at 5 cmH2O results in poor oxygenation and compliance in patients with moderate to severe acute lung injury. Similarly, PEEP set at 25 cmH2O did not improve oxygenation or compliance.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
ckyyds发布了新的文献求助10
1秒前
今后应助天意采纳,获得10
3秒前
grammays完成签到,获得积分10
5秒前
大秦发布了新的文献求助10
6秒前
Orange应助左白易采纳,获得10
6秒前
6秒前
李健应助清秋夜露白采纳,获得10
7秒前
张文博完成签到,获得积分10
7秒前
9秒前
芯之痕发布了新的文献求助10
10秒前
10秒前
冰糖雪梨完成签到,获得积分10
12秒前
puichi关注了科研通微信公众号
14秒前
小方发布了新的文献求助10
14秒前
哪吒关注了科研通微信公众号
15秒前
wendy发布了新的文献求助10
15秒前
16秒前
赖晨靓发布了新的文献求助10
16秒前
高大的傲雪给高大的傲雪的求助进行了留言
17秒前
18秒前
18秒前
辛勤长颈鹿完成签到 ,获得积分10
19秒前
20秒前
wyh完成签到 ,获得积分20
20秒前
24秒前
HansStone发布了新的文献求助30
24秒前
莫里亚蒂完成签到,获得积分10
25秒前
冷眸发布了新的文献求助10
26秒前
27秒前
28秒前
28秒前
赵雨霏完成签到 ,获得积分10
29秒前
29秒前
30秒前
脑洞疼应助小方采纳,获得10
30秒前
32秒前
32秒前
33秒前
YY发布了新的文献求助10
34秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976512
求助须知:如何正确求助?哪些是违规求助? 3520548
关于积分的说明 11203949
捐赠科研通 3257210
什么是DOI,文献DOI怎么找? 1798648
邀请新用户注册赠送积分活动 877835
科研通“疑难数据库(出版商)”最低求助积分说明 806555