谷胱甘肽
流出
运输机
谷胱甘肽转移酶
多重耐药
抗药性
谷胱甘肽S-转移酶
酶
ATP结合盒运输机
表型
药品
生物
生物化学
化学
药理学
基因
遗传学
作者
A. C. SAU,Francesca Pellizzari Tregno,Francesco Valentino,Giorgio Federici,Anna Maria Caccuri
标识
DOI:10.1016/j.abb.2010.05.012
摘要
Chemoresistance is a multifactorial phenomenon and many studies clearly show that a coordinated expression of efflux transporter proteins and phase II conjugating enzymes in tumor cells is linked to the development of the multidrug resistance phenotype. In particular, the overexpression of glutathione S-transferases and efflux pumps in tumors may reduce the reactivity of various anticancer drugs. In recent years it has become evident that glutathione S-transferases are also involved in the control of apoptosis through the inhibition of the JNK signaling pathway. As such, the glutathione S-transferase superfamily has become the focus of extensive pharmaceutical research in attempt to generate more efficient anticancer agents. Here we present an overview of the GST inhibitors and the GST-activated pro-drugs utilized to date to overcome drug resistance.
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