吞噬体
布雷菲尔德A
细胞生物学
抗原呈递
MHC I级
胞浆
吞噬作用
抗原
主要组织相容性复合体
抗原处理
化学
交叉展示
CD8型
生物
生物化学
T细胞
免疫学
高尔基体
免疫系统
酶
内质网
作者
Magdalena Kovacsovics-Bankowski,Kenneth L. Rock
出处
期刊:Science
[American Association for the Advancement of Science]
日期:1995-01-13
卷期号:267 (5195): 243-246
被引量:886
标识
DOI:10.1126/science.7809629
摘要
Peptides from endogenous proteins are presented by major histocompatibility complex class I molecules, but antigens (Ags) in the extracellular fluids are generally not. However, pathogens or particulate Ags that are internalized into phagosomes of macrophages (MØs) stimulate CD8 T cells. The presentation of these Ags is resistant to chloroquine but is blocked by inhibitors of the proteasome, a mutation in the TAP1-TAP2 transporter, and brefeldin A. Moreover, phagocytosis of a ribosomal-inactivating protein inhibited MØ protein synthesis. These results demonstrate that MØs transfer Ags from phagosomes into the cytosol and that endogenous and exogenous Ags use a final common pathway for class I presentation.
科研通智能强力驱动
Strongly Powered by AbleSci AI