白细胞介素15
细胞生物学
内体
生物
CD8型
细胞
白细胞介素
免疫系统
免疫学
细胞因子
生物化学
细胞内
作者
Sigrid Dubois,Jennifer Mariner,Thomas A. Waldmann,Yutaka Tagaya
出处
期刊:Immunity
[Cell Press]
日期:2002-11-01
卷期号:17 (5): 537-547
被引量:870
标识
DOI:10.1016/s1074-7613(02)00429-6
摘要
We report intriguing aspects of the contribution of IL-15Rα to IL-15 functions. Consistent with high-affinity interactions between IL-15 and IL-15Rα, these two molecules form stable complexes on the cell surface of activated monocytes. The formation of IL-15/IL-15Rα complexes on cell surfaces induces a trans-endosomal recycling of IL-15 leading to the persistence of surface-bound IL-15 due to the constantreappearance of IL-15 on plasma membranes. This complex contributes to the long survival of T cells expressing IL-15Rα after IL-15 withdrawal. Finally, these complexes on activated monocytes present IL-15 in trans to target cells such as CD8+ T cells that express only IL-2/15Rβ and γc upon cell-cell interaction.
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