主轴检查点
动细胞
染色体分离
细胞生物学
有丝分裂
G2-M DNA损伤检查点
生物
有丝分裂出口
染色体
细胞周期检查点
遗传学
主轴装置
细胞分裂
细胞周期
癌症
基因
细胞
作者
Andrea Musacchio,Edward D. Salmon
摘要
The spindle-assembly checkpoint is a safety device that monitors the attachment of spindle microtubules to kinetochores and ensures the fidelity of chromosome segregation in mitosis. Molecular studies are finally starting to reveal the mechanisms of checkpoint activation and inactivation.
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