免疫学
免疫系统
细胞因子
自身免疫性疾病
抗原呈递
髓样
炎症
树突状细胞
粒细胞巨噬细胞集落刺激因子
生物
造血
自身免疫
医学
T细胞
细胞生物学
干细胞
抗体
作者
Bao‐Zhu Li,Qian-Ling Ye,Wang‐Dong Xu,Jiehua Li,Dong‐Qing Ye,Yuekang Xu
出处
期刊:Autoimmunity
[Informa]
日期:2013-06-21
卷期号:46 (7): 409-418
被引量:15
标识
DOI:10.3109/08916934.2013.803533
摘要
Autoimmune diseases arise from an inappropriate immune response against self components, including macromolecules, cells, tissues, organs etc. They are often triggered or accompanied by inflammation, during which the levels of granulocyte macrophage colony-stimulating factor (GM-CSF) are elevated. GM-CSF is an inflammatory cytokine that has profound impact on the differentiation of immune system cells of myeloid lineage, especially dendritic cells (DCs) that play critical roles in immune initiation and tolerance, and is involved in the pathogenesis of autoimmune diseases. Although GM-CSF was discovered decades ago, recent studies with some new findings have shed an interesting light on the old hematopoietic growth factor. In the inflammatory autoimmune diseases, GM-CSF redirects the normal developmental pathway of DCs, conditions their antigen presentation capacities and endows them with unique cytokine signatures to affect autoimmune responses. Here we review the latest advances in the field, with the aim of demonstrating the effects of GM-CSF on DCs and their influences on autoimmune diseases. The summarized knowledge will help to design DC-based strategies for the treatment of autoimmune diseases.
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