红藻氨酸受体
神经科学
长期抑郁
代谢型谷氨酸受体
突触可塑性
沉默突触
生物
谷氨酸受体
变质塑性
C级GPCR
离子通道连接受体
AMPA受体
NMDA受体
代谢受体
可塑性
神经可塑性
化学
致电离效应
受体
细胞生物学
长时程增强
谷氨酸的
生物化学
作者
Talvinder S. Sihra,Gonzalo Flores,Antonio Rodríguez‐Moreno
标识
DOI:10.1177/1073858413478196
摘要
Ionotropic glutamate receptors of the N-methyl-d-aspartate (NMDA)- and AMPA-type, as well as metabotropic glutamate receptors have been extensively invoked in plasticity. Until relatively recently, however, kainate-type receptors (KARs) had been the most elusive to study because of the lack of appropriate pharmacological tools to specifically address their roles. With the development of selective glutamate receptor antagonists, and knockout mice with specific KAR subunits deleted, the functions of KARs in neuromodulation and synaptic transmission, together with their involvement in some types of plasticity, have been extensively probed in the central nervous system. In this review, we summarize the findings related to the roles of KARs in short- and long-term forms of plasticity, primarily in the hippocampus, where KAR function and synaptic plasticity have received avid attention.
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