Due to the limitation of dimension, the cooling of microelectronic devices with high heat flux may be sometimes beyond the reach of heat sink which is fabricated with single layer structure, no matter which kind of mircochannel you choose. Various innovative methods have been investigated to tackle this problem. Among them, microchannel heat sink with multilayer structure is possibly one of the most effective cooling techniques. In this paper, the conjugate fluid flow and heat transfer characteristics of multilayer fractal-like microchannel network embedded in a disk-shape heat sink are investigated using a CFD approach. The intrinsic advantages of multilayer fractal-like microchannel network compared with single layer one are demonstrated, such as low total pressure drop, low maximum temperature, and temperature uniformity.