Suppression of Prostaglandin E2by Malaria Parasite Products and Antipyretics Promotes Overproduction of Tumor Necrosis Factor–α: Association with the Pathogenesis of Childhood Malarial Anemia

肿瘤坏死因子α 免疫学 血凝蛋白 寄生虫血症 外周血单个核细胞 发病机制 疟疾 恶性疟原虫 生物 前列腺素E2 医学 内分泌学 生物化学 体外
作者
Christopher C. Keller,Gregory C. Davenport,Katherine R. Dickman,James B. Hittner,Sandra S. Kaplan,J. Brice Weinberg,Peter G. Kremsner,Douglas J Perkins
出处
期刊:The Journal of Infectious Diseases [Oxford University Press]
卷期号:193 (10): 1384-1393 被引量:34
标识
DOI:10.1086/503047
摘要

Cytokines and effector molecules are important immunoregulatory molecules in human malaria. Tumor necrosis factor (TNF)–α limits malaria parasitemia but also promotes pathogenesis at high concentrations, whereas prostaglandin E2 (PGE2) inhibits TNF-α production and is reduced in childhood malaria, at least in part, through suppression of cyclooxygenase (COX)–2 following the ingestion of Plasmodium falciparum hemozoin (pfHz; malarial pigment) by peripheral blood mononuclear cells (PBMCs). Although molecular interactions between TNF-α and PGE2 are largely unexplored in human malaria, results presented here show that pfHz-induced suppression of PBMC COX-2 gene products induces overproduction of TNF-α. Moreover, addition of exogenous PGE2 to pfHz-treated PBMCs dose-dependently decreased TNF-α production, whereas experimental COX inhibitors and antipyretics used during human malaria generated increased TNF-α production. Healthy, malaria-exposed children had elevated levels of circulating bicyclo-PGE2/TNF-α, compared with children with malarial anemia (P<.01), with systemic bicyclo-PGE2 and TNF-α significantly associated with hemoglobin concentrations (r=0.745; P<.01). The results of the present study illustrate that pfHz-induced suppression of PGE2 promotes overproduction of TNF-α, which is associated with enhanced malarial anemia
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
meethaha完成签到,获得积分10
刚刚
1秒前
1秒前
1秒前
2秒前
岳阳张震岳完成签到,获得积分10
2秒前
3秒前
3秒前
5秒前
5秒前
张嘉欣关注了科研通微信公众号
6秒前
6秒前
6秒前
北彧发布了新的文献求助10
6秒前
YAMO一发布了新的文献求助10
7秒前
7秒前
7秒前
8秒前
mike5492完成签到,获得积分10
8秒前
Air云发布了新的文献求助10
9秒前
mm发布了新的文献求助10
9秒前
9秒前
天天快乐应助noah采纳,获得10
10秒前
10秒前
10秒前
iNk应助冷傲凝琴采纳,获得20
11秒前
啊薛薛薛完成签到,获得积分10
11秒前
13秒前
痞老板发布了新的文献求助10
13秒前
你看起来很好吃完成签到,获得积分10
13秒前
shirelylee发布了新的文献求助10
13秒前
科研通AI5应助北彧采纳,获得10
14秒前
orixero应助yy采纳,获得10
15秒前
香蕉觅云应助看着风采纳,获得10
15秒前
CodeCraft应助给大佬递茶采纳,获得10
15秒前
生菜发布了新的文献求助10
16秒前
Akim应助鲤鱼谷南采纳,获得10
16秒前
华仔应助kitsuki采纳,获得10
17秒前
17秒前
tenacity发布了新的文献求助10
17秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3971791
求助须知:如何正确求助?哪些是违规求助? 3516425
关于积分的说明 11182785
捐赠科研通 3251636
什么是DOI,文献DOI怎么找? 1796048
邀请新用户注册赠送积分活动 876216
科研通“疑难数据库(出版商)”最低求助积分说明 805371