Inhibitory effect of topical Adelmidrol on antigen-induced skin wheal and mast cell behavior in a canine model of allergic dermatitis

猪蛔虫 小猎犬 医学 肥大细胞 抗原 药理学 免疫学 内科学 蠕虫
作者
Santiago Grau Cerrato,Pilar Brazı́s,Maria Federica della Valle,Alda Miolo,Anna Puigdemont
出处
期刊:BMC Veterinary Research [Springer Nature]
卷期号:8 (1) 被引量:19
标识
DOI:10.1186/1746-6148-8-230
摘要

Abstract Background Adelmidrol is a semisynthetic derivative of azelaic acid and analogue of the anti-inflammatory compound palmitoylethanolamide (PEA). Based upon its physicochemical properties, adelmidrol is suitable for topical application. The main objective of the present study was to evaluate the efficacy of a topical adelmidrol emulsion on early and late inflammatory responses in hypersensitive dogs. Repeated intradermal injections of Ascaris suum extract were performed in both lateral thoracic areas of six conscious hypersensitive Beagle dogs, topically treated during 8 consecutive days. Adelmidrol (2%) was applied to one side and vehicle to the other. 24 hours after the last antigen challenge, two biopsies (adelmidrol- and vehicle-treated side) were obtained for each dog at the antigen injection site. Results A significant reduction in the antigen-induced wheal areas was observed on the 4 th and 7 th day of adelmidrol treatment. Moreover, cutaneous mast cell numbers were significantly decreased in biopsies obtained after 8 consecutive days of topical adelmidrol treatment. Conclusions The results obtained in the present study show that topical treatment with adelmidrol might represent a new therapeutic tool in controlling the early and late allergic inflammatory skin responses in companion animals.

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