Running speed and maximal oxygen uptake in rats and mice: practical implications for exercise training

最大VO2 单调的工作 强度(物理) 氧气 培训(气象学) 耐力训练 高强度间歇训练 运动强度 运行经济 工作(物理) 有氧运动 间歇训练 动物科学 物理疗法 医学 心率 物理医学与康复 模拟 化学 计算机科学 内科学 生物 物理 血压 热力学 有机化学 量子力学 气象学
作者
Morten A. Høydal,Ulrik Wisløff,Ole Johan Kemi,Øyvind Ellingsen
出处
期刊:European journal of cardiovascular prevention & rehabilitation [SAGE Publishing]
卷期号:14 (6): 753-760 被引量:317
标识
DOI:10.1097/hjr.0b013e3281eacef1
摘要

Valid and reliable experimental models are essential to gain insight into the cellular and molecular mechanisms underlying the beneficial effects of exercise in prevention, treatment, and rehabilitation of lifestyle-related diseases. Studies with large changes, low variation, and reproducible training outcome require individualized training intensity, controlled by direct measurements of maximal oxygen uptake or heart rate. As this approach is expensive and time consuming, we discuss whether maximal treadmill running speed in a gradually increasing ramp protocol might be sufficient to control intensity without losing accuracy. Combined data from six studies of rats and mice from our lab demonstrated a close correlation between running speed and oxygen uptake. This relationship changed towards a steeper linear slope after endurance training, indicating improved work economy, that is, less oxygen was consumed at fixed submaximal running speeds. Maximal oxygen uptake increased 40-70% after high-intensity aerobic interval training in mice and rats. The speed at which oxygen uptake reached a plateau, increased in parallel with the change in maximal oxygen uptake during the training period. Although this suggests that running speed can be used to assess training intensity throughout a training program, the problem is to determine the exact relative intensity related to maximal oxygen uptake from running speed alone. We therefore suggest that directly measured oxygen uptake should be used to assess exercise intensity and optimize endurance training in rats and mice. Running speed may serve as a supplement to ensure this intensity.
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