Effect of a new synbiotic supplement on symptoms, stool consistency, intestinal transit time and gut microbiota in patients with severe functional constipation: a pilot randomized double-blind, controlled trial

合生元 医学 便秘 功能性便秘 内科学 胃肠病学 随机对照试验 益生元 肠道菌群 梭杆菌门 粪便 益生菌 临床终点 食品科学 免疫学 生物 拟杆菌 细菌 古生物学 遗传学 16S核糖体RNA
作者
Gabriele Bazzocchi,Tiziana Giovannini,C. Giussani,Patrizia Brigidi,Silvia Turroni
出处
期刊:Techniques in Coloproctology [Springer Science+Business Media]
卷期号:18 (10): 945-953 被引量:26
标识
DOI:10.1007/s10151-014-1201-5
摘要

Data on the benefits of synbiotics in functional constipation are conflicting. The aim of this study was to assess whether the administration of the synbiotic supplement Psyllogel Megafermenti(®) normalized stool consistency and decreased intestinal transit time (ITT) in patients with severe functional constipation, based on its ability to impact on the gut microbiota.We conducted a pilot randomized, double-blind, controlled trial. After a 2-week run-in period, patients from a tertiary care setting with severe functional constipation fulfilling the Rome III Diagnostic Criteria in the past year were randomly assigned to receive by mouth 2 bags/day of Psyllogel Megafermenti(®) (Group A) or 2.8 g of maltodextrin twice daily (Group B) for 8 weeks. Primary endpoints were increase of bowel evacuations with normal stool consistency and volume, and ITT reduction. Secondary endpoints included symptom improvement according to the Rome III Diagnostic Criteria, reduction of the Agachan-Wexner score and changes in gut microbiota composition.Twenty-nine patients completed the study: 17 were allocated to Group A and 12 to Group B. A statistically significant increase in stools with normal consistency was observed only in Group A (p = 0.001), even when considering patients with normal stools ≤50 % of time at baseline. In Group A, a significant reduction in ITT was also found (p = 0.022). According to polymerase chain reaction-denaturing gradient gel electrophoresis profiling of stool samples, 50 % of the patients treated with synbiotics harbored all the probiotic species of the study product.An 8-week treatment with Psyllogel Megafermenti(®) improved the main clinical parameters of functional constipation in patients extremely homogeneous for disorder severity and underlying pathophysiology ( Eudract.ema.europa.eu , No. 2008-000913-30).
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
无花果应助xxxxfiona采纳,获得10
1秒前
在水一方应助IanYoung71采纳,获得10
1秒前
失眠迎松发布了新的文献求助30
1秒前
1秒前
啦啦啦完成签到,获得积分20
1秒前
瓜子发布了新的文献求助20
1秒前
思源应助呆萌代桃采纳,获得10
2秒前
kidult完成签到,获得积分10
4秒前
今后应助抛向天空采纳,获得10
4秒前
学术裁缝发布了新的文献求助10
4秒前
5秒前
烈日骄阳完成签到,获得积分10
5秒前
5秒前
我是老大应助繁星若尘采纳,获得10
6秒前
星辰大海应助Galaxy采纳,获得10
6秒前
研友_Zzy1pn发布了新的文献求助10
6秒前
陈先生完成签到,获得积分10
8秒前
英吉利25发布了新的文献求助10
8秒前
大方仰发布了新的文献求助20
8秒前
9秒前
狂吃五碗饭完成签到,获得积分10
9秒前
IanYoung71发布了新的文献求助10
9秒前
9秒前
11秒前
养菌人完成签到,获得积分10
11秒前
11秒前
Dritsw应助labxgr采纳,获得10
11秒前
wanci应助忧虑的代容采纳,获得50
12秒前
凯凯完成签到,获得积分10
12秒前
JS发布了新的文献求助10
13秒前
烟花应助学术裁缝采纳,获得10
13秒前
14秒前
EasonYan发布了新的文献求助10
14秒前
dypdyp应助ZH采纳,获得10
14秒前
东日发布了新的文献求助10
14秒前
Leilei完成签到,获得积分20
14秒前
呆萌代桃发布了新的文献求助10
14秒前
万能图书馆应助yan123采纳,获得10
15秒前
小二郎应助俊逸的代曼采纳,获得10
15秒前
16秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3969458
求助须知:如何正确求助?哪些是违规求助? 3514286
关于积分的说明 11173363
捐赠科研通 3249652
什么是DOI,文献DOI怎么找? 1794948
邀请新用户注册赠送积分活动 875501
科研通“疑难数据库(出版商)”最低求助积分说明 804836