Observations on Metabolism of Aldosterone in Man

Article1 July 1963Observations on Metabolism of Aldosterone in ManJ. A. LUETSCHER, M.D., C. A. CAMARGO, M.D., A. P. COHN, M.D., A. J. DOWDY, A. M. CALLAGHANJ. A. LUETSCHER, M.D., C. A. CAMARGO, M.D., A. P. COHN, M.D., A. J. DOWDY, A. M. CALLAGHANAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-1-1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the evaluation of adrenal cortical function by laboratory tests, the essential diagnostic data are the concentrations of hormones in plasma or their metabolites in urine. After a baseline has been established, stimulation with corticotrophin (ACTH) and suppression with dexamethasone give valuable information on adrenal responsiveness to and dependence on ACTH and on the inhibition of pituitary ACTH secretion. The present report deals with the interpretation of the basal measurements in patients with different rates of secretion or metabolism. Since some excellent reports on the secretion and metabolism of cortisol have been published (1), special attention will be directed to...References1. PETERSON RE: The miscible pool and turnover rate of adrenocortical steroids in man. Rec. Progr. Hormone Res. 15: 231, 1959. Google Scholar2. AXELRADCATESJOHNSONLUETSCHER BJJEBBJA: Aldosterone in urine of normal man and of patients with edema. Its increased recovery after hydrolysis with acid and with beta-glucuronidase. Brit. Med. J. 1: 196, 1955. CrossrefMedlineGoogle Scholar3. LUETSCHERNEHERWETTSTEIN JARA: Isolation of crystalline aldosterone from urine of a nephrotic patient. Experientia 10: 456, 1954. CrossrefMedlineGoogle Scholar4. ULICKLARAGHLIEBERMAN SJHS: Isolation of a urinary metabolite of aldosterone and its use to measure secretion rate of aldosterone by adrenal cortex of man. Trans. Ass. 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Author, Article, and Disclosure InformationAffiliations: Palo Alto, CaliforniaFrom the Department of Medicine, Stanford University School of Medicine, Palo Alto, California.This work was supported by research grant Am-3062 from the National Institutes of Health, United States Public Health Service, which also awarded Career Research support to Dr. Luetscher, and Traineeships in Metabolic Diseases to Drs. Camargo and Cohn.Presented as the John Phillips Memorial Lecture before the Forty-fourth Annual Session of the American College of Physicians, Denver, Colorado, April 1-5, 1963.Requests for reprints should be addressed to J. A. Luetscher, M.D., Metabolic Research, Stanford Medical Center, Palo Alto, California. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHuman steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive reviewHuman Uridine Diphosphate-Glucuronosyltransferase UGT2B7 Conjugates Mineralocorticoid and Glucocorticoid MetabolitesOptimisation of total urinary aldosterone estimation: Comparison with other laboratory methods for assessment of mineralocorticoid statusPrimary AldosteronismEffects of acute, passive hepatic congestion on blood flow and oxygen uptake in the intact liver of the cat.REFERENCESOn the pathogenesis of metabolic alkalosis in hyperaldosteronismRecent Advances in Human Steroid MetabolismPrimary Aldosteronism: Diagnosis and TreatmentControl of Aldosterone SecretionPreoperative diagnosis of primary aldosteronismALDOSTERONE METABOLISM IN CARDIAC FAILURENutrition-Endocrine RelationshipsAldosteron und AldosteronismusAldosteronism 1 July 1963Volume 59, Issue 1_Part_1Page: 1-7KeywordsAdrenocorticotropic hormoneAldosteroneAttentionBlood plasmaCareers in researchMetabolitesPrevention, policy, and public healthResearch grantsSteroidsUrine ePublished: 1 December 2008 Issue Published: 1 July 1963 Copyright & PermissionsCopyright ©, 1963, by The American College of PhysiciansPDF downloadLoading ...