胶原酶
戊二醛
角膜穿孔
穿孔
氰基丙烯酸酯
角膜溃疡
低温保存
角膜
羊膜
眼科
外科
医学
胶粘剂
化学
材料科学
生物
病理
胚胎
冲孔
酶
遗传学
生物化学
胎儿
图层(电子)
冶金
细胞生物学
怀孕
有机化学
作者
Kiyotaka Kitagawa,Motonori Okabe,Shuichiro Yanagisawa,Xueyun Zhang,Toshio Nikaido,Atsushi Hayashi
出处
期刊:Japanese Journal of Ophthalmology
日期:2011-01-01
卷期号:55 (1): 16-21
被引量:24
标识
DOI:10.1007/s10384-010-0903-0
摘要
To report the use of hyperdried cross-linked (HDCL) amniotic membrane (AM) patching with tissue adhesive as an initial therapy for corneal perforations.Cryopreserved AM was cross-linked with 0.1% glutaraldehyde and then dried using far-infrared rays and microwaves (hyperdry method). Three eyes of three patients with corneal perforations of up to 3 mm in diameter were included in this study. They were treated with a single-layer patch of HDCL-AM applied with a tissue adhesive (2-octyl-cyanoacrylate). We also evaluated the resistance of HDCL-AM to collagenases during in vitro digestion testing.In all three cases, the corneal perforations were repaired within 28 days (range, 17-28 days). No recurrence occurred during the follow-up period (3-6 months). In the collagenase digestion testing, the HDCL-AM did not dissolve until 48 h, whereas the cryopreserved AM completely dissolved within 60 min.Three cases of corneal perforations were successfully managed using HDCL-AM patching with tissue adhesive. The HDCL-AM was resistant to collagenases during in vitro digestion testing. The HDCL-AM was a useful substrate for corneal perforations. This simple surgical technique may be one of the initial therapeutic options for corneal perforations.
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