医学
系统性狼疮
免疫学
系统性红斑狼疮
自身抗体
自身免疫性疾病
疾病
药物输送
治疗方法
发病机制
内科学
抗体
纳米技术
材料科学
作者
Davoud Rostamzadeh,Seyed Rasol Razavi,Shadi Esmaeili,Sanam Dolati,Majid Ahmadi,Sanam Sadreddini,Farhad Jadidi‐Niaragh,Mehdi Yousefi
标识
DOI:10.1016/j.biopha.2016.08.020
摘要
Systemic lupus erythematous (SLE) is a chronic heterogeneous multisystem autoimmune disease characterized by loss of tolerance to self-antigens and production of numerous autoantibodies. Current therapeutic approaches used to treat inflammatory autoimmune diseases are associated with debilitating side effects. In spite of significant advances in therapeutic options and increased understanding of the pathogenesis, novel therapeutic approaches are needed for treatment of SLE. Nanoparticle-based delivery systems that selectively deliver drugs to inflamed tissue or specific cell have the potential to improve drug delivery. This article reviews recent nanotechnology-based therapeutics strategies that are being developed for the treatment of SLE.
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