葡萄糖醛酸化
药物代谢
尿苷
化学
葡萄糖醛酸转移酶
酶
尿苷二磷酸
药理学
药品
生物化学
医学
微粒体
基因
核糖核酸
出处
期刊:The Royal Society of Chemistry eBooks
[The Royal Society of Chemistry]
日期:2021-08-19
卷期号:: 278-302
标识
DOI:10.1039/9781788016414-00278
摘要
Glucuronidation catalyzed by uridine 5′-diphospho-glucuronosyltransferase (UGT) is the most common phase II metabolism. The UGTs can severely limit a drug's exposure and generate reactive metabolites, leading to toxicity. This chapter provides a brief overview of the current understanding of the UGT enzyme family, followed by various medicinal chemistry strategies to address this metabolic liability and select examples from the literature.
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