Efficacy and safety of autologous platelet‐rich fibrin for the treatment of infertility with intrauterine adhesions

医学 宫腔镜检查 不育 子宫腔 不利影响 月经周期 怀孕 纤维蛋白 妊娠率 卵泡期 妇科 粘附 泌尿科 产科 子宫 内科学 有机化学 化学 免疫学 生物 激素 遗传学
作者
Zijun Wang,Mukun Yang,Lele Mao,Xiaoxue Wang,Wang Shuowen,Guangxia Cui,Zhaoxi Hou,Min Yang,Lei Cui,Wenpei Bai
出处
期刊:Journal of Obstetrics and Gynaecology Research [Wiley]
卷期号:47 (11): 3883-3894 被引量:8
标识
DOI:10.1111/jog.14964
摘要

To evaluate the efficacy and safety of autologous platelet-rich fibrin (PRF) for the treatment of infertility with intrauterine adhesions.Forty patients who suffered from infertility with intrauterine adhesions (IUAs) were enrolled in this prospective trial from October 2018 to December 2019. They were randomly divided into a PRF group and a control group. Both groups underwent transcervical resection of adhesions (TCRA) during the follicular phase. PRF group: PRF prepared from autologous venous blood was placed in the uterine cavity after TCRA and after the first menstrual re-fluid; control group: no PRF insertion. After the second menstrual re-fluid, both groups underwent hysteroscopy to reevaluate adhesion severity. Pregnancy rate, intrauterine adhesion score, menstrual volume and duration, and endometrial thickness were assessed and adverse events were recorded.(1) PRF group pregnancy rate was significantly higher than the control group (55.0% vs. 20.0%). Mean follow-up time was (17.63 ± 2.33) months. All patients fell pregnant naturally. Four (PRF) and one (control) patients delivered live births without placental complications. (2) Intrauterine adhesion scores decreased compared with treatment-before. (3) In the pictorial blood loss assessment chart, score and menstrual duration during the 3rd menstrual cycle showed significant improvements for both groups. (4) Endometrial thickness also showed an increasing trend, and subendometrial bloodflow improved. (5) No treatment-related serious adverse events were noted.Placing PRF into the uterine cavity of infertility patients with IUAs following TCRA is a safe and effective therapeutic method.
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