A cross-sectional seroepidemiology study of seven major enteroviruses causing HFMD in Guangdong, China

Recent article in this Journal has reported a cohort of study on the seroepidemiology of EV-A71, CV-A16, CV-A6 1 Gao F. Mao Q.Y. Chen P. Bian L.L. Yao X. Li J.X. et al. Seroepidemiology of coxsackievirus A6, coxsackievirus A16, and enterovirus 71 infections in infants and children: a prospective cohort study in Jiangsu, China. J Infect. 2016; 73: 509-512 Abstract Full Text Full Text PDF PubMed Scopus (13) Google Scholar and CV-A10 2 Fu Y. Sun S.Y. Mao Q.Y. Bian L.L. Wu X. Zhu F.C. et al. Seroepidemiology of coxsackievirus A10 infection in infants and children: a prospective cohort study in Jiangsu, China. J Infect. 2018; 77: 158-164 Abstract Full Text Full Text PDF PubMed Scopus (4) Google Scholar in infants and children. In the past two decades, HFMD has occurred frequently worldwide, especially in the Asia-Pacific region, where it has become an important public health problem. 1 Gao F. Mao Q.Y. Chen P. Bian L.L. Yao X. Li J.X. et al. Seroepidemiology of coxsackievirus A6, coxsackievirus A16, and enterovirus 71 infections in infants and children: a prospective cohort study in Jiangsu, China. J Infect. 2016; 73: 509-512 Abstract Full Text Full Text PDF PubMed Scopus (13) Google Scholar ,2 Fu Y. Sun S.Y. Mao Q.Y. Bian L.L. Wu X. Zhu F.C. et al. Seroepidemiology of coxsackievirus A10 infection in infants and children: a prospective cohort study in Jiangsu, China. J Infect. 2018; 77: 158-164 Abstract Full Text Full Text PDF PubMed Scopus (4) Google Scholar Enterovirus A71 (EV-A71), coxsackievirus (CV)-A 16, CV-A6, and CV-A10 are the main pathogens causing HFMD outbreaks and epidemics. 1 Gao F. Mao Q.Y. Chen P. Bian L.L. Yao X. Li J.X. et al. Seroepidemiology of coxsackievirus A6, coxsackievirus A16, and enterovirus 71 infections in infants and children: a prospective cohort study in Jiangsu, China. J Infect. 2016; 73: 509-512 Abstract Full Text Full Text PDF PubMed Scopus (13) Google Scholar ,2 Fu Y. Sun S.Y. Mao Q.Y. Bian L.L. Wu X. Zhu F.C. et al. Seroepidemiology of coxsackievirus A10 infection in infants and children: a prospective cohort study in Jiangsu, China. J Infect. 2018; 77: 158-164 Abstract Full Text Full Text PDF PubMed Scopus (4) Google Scholar However, CV-A2, CV-A4 and CV-A5, in the EV-A group, have emerged as active pathogens implicated in several HFMD and herpangina epidemics worldwide. 3 Lee M.H. Huang L.M. Wong W.W. Wu T.Z. Chiu T.F. Chang L.Y. Molecular diagnosis and clinical presentations of enteroviral infections in Taipei during the 2008 epidemic. J Microbiol Immunol Infect. 2011; 44: 178-183 Crossref PubMed Scopus (20) Google Scholar , 4 Chansaenroj J. Auphimai C. Puenpa J. Mauleekoonphairoj J. Wanlapakorn N. Vuthitanachot V. et al. High prevalence of coxsackievirus A2 in children with herpangina in Thailand in 2015. Virus Dis. 2017; 28: 111-114 Crossref Scopus (13) Google Scholar , 5 Meng X.D. Tong Y. Wei Z.N. Wang L. Mai J.Y. Wu Y. et al. Epidemical and etiological study on hand, foot and mouth disease following EV-A71 vaccination in Xiangyang, China. Sci Rep. 2020; 10: e20909 Crossref PubMed Scopus (6) Google Scholar , 6 Wu Y. Yeo A. Phoon M.C. Tan E.L. Poh C.L. Quak S.H. et al. The largest outbreak of hand; foot and mouth disease in Singapore in 2008: the role of enterovirus 71 and coxsackievirus A strains. Int J Infect Dis. 2010; 14: e1076-e1081 Abstract Full Text Full Text PDF PubMed Scopus (279) Google Scholar , 7 Kokkinos P.A. Ziros P.G. Monini M. Lampropoulou P. Karampini A. Papachatzi E. et al. Rare types of rotaviruses isolated from children with acute gastroenteritis in Patras, Greece. Intervirology. 2013; 56: 237-241 Crossref PubMed Scopus (7) Google Scholar , 8 Li J.S. Dong X.G. Qin M. Xie Z.P. Gao H.C. Yang J.Y. et al. Outbreak of febrile illness caused by coxsackievirus A4 in a nursery school in Beijing, China. Virol J. 2015; 12: 92 Crossref PubMed Scopus (10) Google Scholar , 9 Yamashita T. Ito M. Taniguchi A. Sakae K. et al. Prevalence of coxsackievirus A5, A6, and A10 in patients with herpangina in Aichi Prefecture. Jpn J Infect Dis. 2005; 58: 390-391 PubMed Google Scholar