阿魏酸
纳米纤维素
抗菌剂
细菌生长
化学
纳米晶
纤维素
酸水解
聚乙烯醇
细菌纤维素
食品科学
细菌
材料科学
有机化学
纳米技术
水解
复合材料
生物
遗传学
作者
Syarifah Ab Rashid,Amerrul Ilmi Mohd Razali,Woei Yenn Tong,Chean Ring Leong,Wen‐Nee Tan
标识
DOI:10.1080/15440478.2021.1967827
摘要
Chronic wounds have affected more than 6 million people, especially diabetic populations. Various antimicrobial substances have been added to nanocellulose-based wound dressing to inhibit microbial growth. However, the substances triggered multiple adverse implications on humans. In this communication, we have developed a ferulic acid-grafted cellulose nanocrystal film as a potential antimicrobial material for wound dressing development. Needle-like cellulose nanocrystals, with an average length of 159 ± 31 nm, were extracted from medical-grade cotton using the acid hydrolysis method. A combination of cellulose nanocrystals, polyvinyl alcohol (PVA) and ferulic acid has generated a soft, sturdy, flexible, elastic and non-ductile film. It absorbed a large amount of exudates by presenting a swelling ratio of 774 ± 57%. The release of ferulic acid achieved a plateau at 20 h, with a total release of 75.4 ± 7.9% from the developed film. The ferulic acid-grafted cellulose nanocrystal film inhibited the growth of 2 Gram-positive bacteria, 3 Gram-negative bacteria and 1 yeast. During the Hohenstein challenge and wash durability, the developed film retained its antimicrobial efficiency by reducing up to 82% microbial growth even after 20 washes. The findings exposed that the ferulic acid-grafted cellulose nanocrystal film is effective in combating wound pathogens and ideal for dressing development.
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