疾病
医学
癌症
免疫疗法
机制(生物学)
抗药性
放射治疗
重症监护医学
肿瘤科
内科学
化疗
生物
微生物学
认识论
哲学
作者
Zhe‐Sheng Chen,Lizhu Lin,Sheng-Xiong Zhang,Wei Liu,Bo Ai,Lingling Sun
出处
期刊:Recent Patents on Anti-cancer Drug Discovery
[Bentham Science]
日期:2022-02-01
卷期号:17 (1): 26-41
被引量:18
标识
DOI:10.2174/1574892816666210929165729
摘要
Surgical resection of the lesion is the standard primary treatment of gastric cancer. Unfortunately, most patients are already in the advanced stage of the disease when they are diagnosed with gastric cancer. Alternative therapies, such as radiation therapy and chemotherapy, can achieve only very limited benefits. The emergence of cancer drug resistance has always been the major obstacle to the cure of tumors. The main goal of modern cancer pharmacology is to determine the underlying mechanism of anticancer drugs.Here, we mainly review the latest research results related to the mechanism of chemotherapy resistance in gastric cancer, the application of natural products in overcoming the chemotherapy resistance of gastric cancer, and the new strategies currently being developed to treat tumors based on immunotherapy and gene therapy.The emergence of cancer drug resistance is the main obstacle in achieving alleviation and final cure for gastric cancer. Mixed therapies are considered to be a possible way to overcome chemoresistance. Natural products are the main resource for discovering new drugs specific for treating chemoresistance, and further research is needed to clarify the mechanism of natural product activity in patients.
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