医学
伤口愈合
糖尿病足
炎症
糖尿病
生物信息学
糖尿病足溃疡
治疗方法
信号转导
免疫学
内科学
内分泌学
疾病
细胞生物学
生物
作者
Νικόλαος Παπάνας,Djordje S. Popovic
标识
DOI:10.1177/15347346211029818
摘要
Diabetic foot ulcers (DFUs) remain a common debilitating and costly complication of diabetes mellitus. Indeed, despite all efforts and emerging technologies, many DFUs are difficult to heal and frequently recur. Thus, novel therapeutic approaches are urgently needed. Specific targeting of different molecular and cellular pathways implicated in wound healing emerges as an attractive therapeutic modality to improve outcomes. One of the novel pathways that carry this potential is the wingless-type mouse mammary tumor virus integration site family/beta-catenin signaling pathway (WβcSP). It plays an important role in different stages of wound healing, including inflammation, proliferation, and remodeling. Potential therapeutic implications of WβcSP activation include producing agonists and/or blocking its endogenous inhibitors. Thus, we should perhaps start exploring potential ways of its therapeutic implication to improve DFU healing.
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