癌症
淀粉样前体蛋白
淀粉样蛋白(真菌学)
癌症研究
化学
医学
生物化学
计算生物学
生物信息学
生物
阿尔茨海默病
内科学
病理
疾病
作者
Han Na Lee,Mi Suk Jeong,Se Bok Jang
摘要
Amyloid precursor protein (APP) is a type 1 transmembrane glycoprotein, and its homologs amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) are highly conserved in mammals. APP and APLP are known to be intimately involved in the pathogenesis and progression of Alzheimer’s disease and to play important roles in neuronal homeostasis and development and neural transmission. APP and APLP are also expressed in non-neuronal tissues and are overexpressed in cancer cells. Furthermore, research indicates they are involved in several cancers. In this review, we examine the biological characteristics of APP-related family members and their roles in cancer.
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