医学
膜性肾病
免疫系统
局灶节段性肾小球硬化
免疫学
狼疮性肾炎
发病机制
肾小球肾炎
肾脏疾病
疾病
肾病
肾
血管炎
病理
内科学
糖尿病
内分泌学
作者
Sam Kant,Andreas Kronbichler,Purva Sharma,Duvuru Geetha
标识
DOI:10.1053/j.ajkd.2021.07.019
摘要
There continues to be rapid advancement in our understanding of the pathogenesis of immune-mediated kidney disease. This progress has culminated in the development of multiple therapeutic agents that have consistently improved renal and patient outcomes. The focus of this review is to discuss these recent advancements in immune-mediated kidney disease via the lens of direct and indirect immune-mediated mechanisms. In the direct immune-mediated disease, recently described antigens in anti-glomerular basement membrane (GBM) disease and membranous nephropathy are discussed, along with new therapeutic regimens in membranous nephropathy and focal segmental glomerulosclerosis. From an indirect immune-mediated disease standpoint, recent pivotal trials in antineutrophil cytoplasmic antibody vasculitis, lupus nephritis, and IgA nephropathy are examined from a real-world practice perspective. New molecular pathways in various disorders of alternate complement pathway are described, which in turn have led to development of various experimental therapies. In addition, pivotal and ongoing therapeutic trials in the aforementioned diseases are presented.
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