Relationship of established risk factors with breast cancer subtypes

乳腺癌 医学 肿瘤科 内科学 雌激素受体 家族史 孕酮受体 体质指数 人口 妇科 风险因素 比例危险模型 三阴性乳腺癌 乳腺癌的危险因素 优势比 癌症 队列 逻辑回归 置信区间 危险系数 环境卫生
作者
Anne Marie McCarthy,Tara Friebel-Klingner,Sarah Ehsan,Wei He,Michaela Welch,Jinbo Chen,Despina Kontos,Susan M. Domchek,Emily F. Conant,Alan Semine,Kevin S. Hughes,Aditya Bardia,Constance D. Lehman,Katrina Armstrong
出处
期刊:Cancer Medicine [Wiley]
卷期号:10 (18): 6456-6467 被引量:42
标识
DOI:10.1002/cam4.4158
摘要

Breast cancer is a heterogeneous disease, divided into subtypes based on the expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Subtypes have different biology and prognosis, with accumulating evidence of different risk factors. The purpose of this study was to compare breast cancer risk factors across tumor subtypes in a large, diverse mammography population.Women aged 40-84 without a history of breast cancer with a screening mammogram at three United States health systems from 2006 to 2015 were included. Risk factor questionnaires were completed at mammogram visit, supplemented by electronic health records. Invasive tumor subtype was defined by immunohistochemistry as ER/PR+HER2-, ER/PR+HER2+, ER, and PR-HER2+, or triple-negative breast cancer (TNBC). Cox proportional hazards models were run for each subtype. Associations of race, reproductive history, prior breast problems, family history, breast density, and body mass index (BMI) were assessed. The association of tumor subtypes with screen detection and interval cancer was assessed using logistic regression among invasive cases.The study population included 198,278 women with a median of 6.5 years of follow-up (IQR 4.2-9.0 years). There were 4002 invasive cancers, including 3077 (77%) ER/PR+HER2-, 300 (8%) TNBC, 342 (9%) ER/PR+HER2+, and 126 (3%) ER/PR-HER2+ subtype. In multivariate models, Black women had 2.7 times higher risk of TNBC than white women (HR = 2.67, 95% CI 1.99-3.58). Breast density was associated with increased risk of all subtypes. BMI was more strongly associated with ER/PR+HER2- and HER2+ subtypes among postmenopausal women than premenopausal women. Breast density was more strongly associated with ER/PR+HER2- and TNBC among premenopausal than postmenopausal women. TNBC was more likely to be interval cancer than other subtypes.These results have implications for risk assessment and understanding of the etiology of breast cancer subtypes. More research is needed to determine what factors explain the higher risk of TNBC for Black women.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
小猪完成签到,获得积分10
刚刚
2秒前
萌面大侠完成签到,获得积分10
2秒前
2秒前
金枪鱼完成签到,获得积分10
3秒前
sssssssssss完成签到,获得积分10
3秒前
mary发布了新的文献求助10
5秒前
研友_VZG7GZ应助hahaha123213123采纳,获得10
5秒前
枕星发布了新的文献求助10
7秒前
7秒前
8秒前
8秒前
求求大家了完成签到,获得积分10
8秒前
阳光完成签到,获得积分10
8秒前
Crystal完成签到 ,获得积分10
10秒前
11秒前
11秒前
12秒前
12秒前
12秒前
乐乐应助赖道之采纳,获得10
13秒前
13秒前
Sun_Chen完成签到,获得积分10
13秒前
体贴凌柏发布了新的文献求助10
14秒前
成就的笑南完成签到 ,获得积分10
14秒前
15秒前
15秒前
wyw123完成签到,获得积分10
15秒前
求大佬帮助完成签到,获得积分10
15秒前
李健的小迷弟应助zyq采纳,获得10
16秒前
陈隆完成签到,获得积分10
16秒前
哎呀完成签到 ,获得积分10
16秒前
量子星尘发布了新的文献求助10
17秒前
mary完成签到,获得积分10
17秒前
17秒前
朱成豪发布了新的文献求助10
19秒前
deallyxyz应助科研通管家采纳,获得10
19秒前
科目三应助科研通管家采纳,获得10
19秒前
大个应助科研通管家采纳,获得10
19秒前
比比谁的速度快应助曾珍采纳,获得50
19秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038368
求助须知:如何正确求助?哪些是违规求助? 3576068
关于积分的说明 11374313
捐赠科研通 3305780
什么是DOI,文献DOI怎么找? 1819322
邀请新用户注册赠送积分活动 892672
科研通“疑难数据库(出版商)”最低求助积分说明 815029