鞣花酸
苯硼酸
检出限
聚乙二醇
化学
硼酸
线性范围
石墨烯
酒石酸
色谱法
组合化学
三乙醇胺
核化学
有机化学
纳米技术
分析化学(期刊)
材料科学
多酚
催化作用
抗氧化剂
柠檬酸
作者
Luxia Zhang,Rui Duan,Yuan-Shuo Yang,Chao Peng,Lijie Dong,Xianhua Wang
标识
DOI:10.1016/j.snb.2021.130400
摘要
Herein, we integrate boronate-affinity controllable-oriented ellagic acid-imprinted magnetic nanoparticles (BCEMN) and boronic acid-modified / polyethylene glycol-coated allochroic-graphene oxide (BPAO) for specific and ultrasensitive detection of ellagic acid (EA). The novel detection method depends on a dual boronate-affinity sandwich strategy. The symmetric EA is first specifically captured by the BCEMN based on the boronate-affinity-related molecularly imprinted recognition, and then labeled with BPAO due to the boronate-affinity recognition. The BPAO, which is functionalized with 2,6-difluoro-4-formyl-phenylboronic acid, loaded with a large amount of pH-sensitive thymol phthalide and coated with hydrophilic polyethylene glycol, can specifically recognize the cis-diol of EA at physiological condition (pH 7.4) and perform signal amplification and readout through pH-triggered allochroism. Furthermore, the signal readout of allochroism is linear with the logarithm of EA concentration over the range between 0.02 ng mL−1 to 104 ng mL−1 with a good correlation coefficient (R2 = 0.993), and the limit of detection (LOD) is 2.96 pg mL−1. Finally, the BCEMN linked BPAO (BCBP) strategy has also been successfully applied in the detection of EA concentration in spiked strawberry sample with recovery and relative standard deviation in the range of 84.9%–110.2% and 3.9%–6.1%, respectively.
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