神经科学
运动皮层
神经可塑性
神经传递
心理学
上瘾
突触可塑性
医学
刺激
内科学
受体
作者
Tong Cheng,Xiaodan Huang,Xuefei Hu,Siqi Wang,Kai Chen,Ji‐an Wei,Lan Yan,KF So,Ti‐Fei Yuan,Li Zhang
标识
DOI:10.1038/s41380-021-01336-2
摘要
Drug exposure impairs cortical plasticity and motor learning, which underlies the reduced behavioral flexibility in drug addiction. Physical exercise has been used to prevent relapse in drug rehabilitation program. However, the potential benefits and molecular mechanisms of physical exercise on drug-evoked motor-cortical dysfunctions are unknown. Here we report that 1-week treadmill training restores cocaine-induced synaptic deficits, in the form of improved in vivo spine formation, synaptic transmission, and spontaneous activities of cortical pyramidal neurons, as well as motor-learning ability. The synaptic and behavioral benefits relied on de novo protein synthesis, which are directed by the activation of the mechanistic target of rapamycin (mTOR)-ribosomal protein S6 pathway. These findings establish synaptic functional restoration and mTOR signaling as the critical mechanism supporting physical exercise training in rehabilitating the addicted brain.
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