吸附
傅里叶变换红外光谱
差示扫描量热法
化学
赋形剂
结晶度
化学工程
扫描电子显微镜
插层(化学)
镁
材料科学
无机化学
有机化学
色谱法
结晶学
工程类
物理
复合材料
热力学
作者
Vandana Kharb,Vikas Anand Saharan,Vivek Kharb,Hemant R. Jadhav,Suresh Purohit
标识
DOI:10.3109/03639045.2015.1128439
摘要
Taste masking greatly influences the acceptability of bitter tasting formulation; moreover, it governs the commercial and therapeutic success of drug products.This work is directed toward masking the bitter taste of ondansetron HCl (ONS) utilizing the excipient, which can delay the reach of drug to the taste buds.Magnesium aluminum silicate (Veegum F), a clay material having capability to adsorb the drugs onto it, was used. The adsorption systems of ONS with Veegum were obtained by dynamic adsorption technique and examined by scanning electron microscopy, differential scanning calorimetry, Fourier transform infrared (FTIR) spectroscopy, and X-ray diffraction (XRD) for morphology, thermal behavior, and interactions. The taste assessment of prepared systems was done by in vitro method based on drug release.The molecular interaction between ONS and Veegum in the system was revealed by FTIR spectroscopy. A change in thermal behavior of the system was observed owing to interaction or replacement of the cationic groups of Veegum with that of ONS. XRD studies revealed that the prepared system was having lower crystallinity as compared to ONS. The in vitro drug release study showed that ONS release from the system was relatively slow in basic environment than the acidic one.Adsorption of ONS on the surface of Veegum was mainly due to electrostatic interactions and hydrogen bonding.The experimental results reveal the successful intercalation of ONS into the space available between the layers of Veegum. Furthermore, this resulted in a control on drug release in salivary pH resulting in a concentration lower than bitterness threshold.
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