Syncope and cardiac arrest during strenuous exercise associated with a novel mutation in LQTS1

Key Clinical Message Exercise‐induced syncope should alert clinicians to the possibility of LQTS and must be distinguished from other malignant causes of syncope such as hypertrophic cardiomyopathy, catecholaminergic ventricular tachycardia, and arrhythmogenic right ventricular cardiomyopathy. Emerging genotype–phenotype links have connected mutations resulting in LQTS with risk of developing atrial fibrillation and cardiomyopathy.