Niclosamide: An Established Antihelminthic Drug as a Potential Therapy Against S100A4-Mediated Metastatic Colon Tumors

Progression of cancers because of the ability of primary tumor cells to grow outside their local environment and spread to distant sites (metastasize) is a major problem and a major cause of death from cancers. Patients with non-metastatic local stage I tumor have a 5-year survival rate of 90%, which drops to approximately 10% in patients with distant metastasis at the time of diagnosis. Therefore, it is important to identify genes that mediate metastasis and develop effective therapies against these potential targets.