芳基
化学
芳基
组分(热力学)
四氢呋喃
组合化学
功能群
密度泛函理论
分子
偶联反应
计算化学
药物化学
有机化学
催化作用
热力学
物理
聚合物
烷基
溶剂
作者
Subrata Bhattacharjee,Shiksha Deswal,Niket Manoj,Garima Jindal,Matteo Zanda
出处
期刊:Organic Letters
[American Chemical Society]
日期:2021-11-16
卷期号:23 (23): 9083-9088
被引量:32
标识
DOI:10.1021/acs.orglett.1c03378
摘要
A facile synthesis of biologically important S-aryl dithiocarbamates has been demonstrated by the aryne three-component coupling involving CS2 and aliphatic amines. This transition-metal-free and mild reaction is scalable and operates with good functional group compatibility. Preliminary mechanistic experiments, including density functional theory studies, are also provided. Moreover, with 3-triflyloxybenzynes, a unique four-component coupling incorporating tetrahydrofuran was observed.
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