肌萎缩侧索硬化
连接蛋白
疾病
神经科学
生物
谷氨酸受体
变性(医学)
退行性疾病
程序性细胞死亡
亨廷顿病
神经元变性
神经退行性变
细胞凋亡
病理
缝隙连接
医学
细胞生物学
细胞内
受体
生物化学
作者
Juping Xing,Changshui Xu
出处
期刊:Molecular Medicine Reports
[Spandidos Publications]
日期:2021-03-23
卷期号:23 (5)
被引量:4
标识
DOI:10.3892/mmr.2021.12034
摘要
Neurodegenerative diseases are neurological disorders characterized by progressive neuronal degeneration, such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis and Huntington's disease. The neuronal damage caused by these diseases may be associated with abnormal alterations of connexins in glia. These changes may cause glia to lose their ability to support and protect neurons and induce abnormal increases in levels of ions and metabolites, such as calcium ions, glutamate and ATP, around neurons. These processes eventuallys lead to neuronal death. In the present review, the abnormal expression of connexin and its primary role in neurodegenerative diseases was investigated.
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