增粘剂
透明质酸
生物相容性
骨关节炎
医学
生物医学工程
化学
药理学
病理
解剖
有机化学
替代医学
关节内
作者
Grzegorz Szczęsny,Wiesław Tomaszewski,Marcin Domżalski
出处
期刊:Ortopedia, traumatologia, rehabilitacja
[Index Copernicus International]
日期:2021-06-22
卷期号:23 (3): 229-238
被引量:1
标识
DOI:10.5604/01.3001.0014.9625
摘要
The discovery of unique properties of the hyaluronic acid and learning about the role of this aid in pathophysiology of extracellular matrices resulted in using this substance in pharmacological support in cases of tissue dysfunction due to numerous disease units. Therefore, the products containing this substance are now widely used in medicine including dermatology and aesthetic medicine, ophthalmology, facial-mandibular surgery and orthopedics, being among the most effective products used in the treatment of numerous cases of function impairment and deformation of tissues and organs. There are applied in both post-traumatic and post-inflammatory conditions as well as in symptoms due to chronic conditions. Their therapeutic effects result from joint surface moisturizing, reduction of the coefficient of friction (COF) and good bio-tolerance and biocompatibility confirmed by a low percentage of side effects and biocompatibility. The introduction of hyaluronic acid hybrid complexes with high and low molecular mass (H/L-HA) has increased the clinical usefulness of hyaluronic acid products thanks to their increased viscoelasticity, increased anti-inflammatory and chondroprotective properties and thermodynamic stabilization of the product guaranteeing its half-life. Thanks to the above mentioned pro-perties it becomes more effective in the non-surgical treatment of osteoarthritis.
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