亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Aspirin for preventing adverse outcomes in low risk nulliparous women with singleton pregnancies: A systematic review and meta-analysis

医学 阿司匹林 产科 子痫 子痫前期 流产 相对风险 怀孕 小于胎龄 荟萃分析 置信区间 妊娠期糖尿病 胎龄 妊娠期 内科学 生物 遗传学
作者
Rebecca Man,Victoria Hodgetts Morton,Pooja Devani,R. Katie Morris
出处
期刊:European Journal of Obstetrics & Gynecology and Reproductive Biology [Elsevier]
卷期号:262: 105-112 被引量:14
标识
DOI:10.1016/j.ejogrb.2021.05.017
摘要

Abstract

Objective

To assess the effects of aspirin in pregnancy for the prevention of adverse outcomes in low risk, nulliparous women with singleton pregnancies.

Study design

Medline, Embase, CINAHL, the Cochrane library, Web of Science and clinicaltrials.gov were searched from inception until February 2020. Randomised controlled trials were eligible for inclusion where women were nulliparous, had singleton pregnancies and no other risk factors for pre-eclampsia such as diabetes or pre-existing hypertension. Primary outcomes were pre-eclampsia, gestational hypertension and eclampsia. Secondary outcomes included; pre-term birth, postpartum haemorrhage, antepartum haemorrhage, miscarriage, small for gestational age (SGA), fetal growth restriction (FGR), birthweight and further markers of maternal and neonatal morbidity and mortality. The results were combined into meta-analysis where appropriate.

Results

Ten studies were eligible for inclusion involving 23,162 women. Two studies (involving 214 women) used aspirin doses of 100 mg, with the remainder using smaller doses. There was no significant difference found in the risk of developing pre-eclampsia between women receiving aspirin compared to no aspirin (relative risk [RR] 0.70, 95 % confidence interval [CI] 0.47–1.05, p=0.08). Women receiving aspirin had a reduced risk of having a preterm birth <34 weeks (RR 0.50, 95 % CI 0.26−0.96, p=0.04), and reduced risk of having a SGA neonate (RR 0.94, 95 % CI 0.89–1.00, p=0.04). An increase in birthweight was seen when aspirin was received (mean difference 105.17 g, 95 % CI 12.38 g–197.96 g, p=0.03) and there was no increase in risk of postpartum or antepartum haemorrhage in those receiving aspirin (RR 1.24, 95 % CI 0.90–1.71, p=0.19 and RR 1.06, 95 % CI 0.66–1.70, p=0.81 respectively).

Conclusion

The results did not demonstrate a significant difference amongst low risk nulliparous women in the risks of pre-eclampsia or gestational hypertensive disorders with aspirin administration. Although we found significantly improved fetal growth parameters and prevention of preterm birth in women receiving aspirin, there were few eligible studies, with those included generally providing low quality evidence and many studies using aspirin doses ≤100 mg, commenced late in pregnancy. More research in the form of a high quality randomised controlled trial is needed before recommendations can be made.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
amengptsd完成签到,获得积分10
5秒前
左囧完成签到,获得积分10
21秒前
zqq完成签到,获得积分0
31秒前
49秒前
Super Spine完成签到 ,获得积分10
59秒前
1分钟前
2分钟前
所所应助斯文绿凝采纳,获得10
2分钟前
2分钟前
Mia发布了新的文献求助10
2分钟前
Ann1203完成签到,获得积分10
3分钟前
3分钟前
李爱国应助Ann1203采纳,获得10
3分钟前
早坂爱发布了新的文献求助10
3分钟前
3分钟前
刘天宇完成签到 ,获得积分10
3分钟前
HEIKU应助早坂爱采纳,获得10
3分钟前
hhl完成签到,获得积分10
3分钟前
李静发布了新的文献求助10
3分钟前
breeze完成签到,获得积分10
3分钟前
Akim应助thousandlong采纳,获得10
4分钟前
4分钟前
thousandlong发布了新的文献求助10
4分钟前
4分钟前
小铁板发布了新的文献求助10
4分钟前
4分钟前
布通发布了新的文献求助10
4分钟前
小铁板完成签到,获得积分10
4分钟前
zzxp完成签到,获得积分10
5分钟前
脑洞疼应助aaa采纳,获得10
5分钟前
烟花应助布通采纳,获得10
5分钟前
5分钟前
TAO LEE完成签到 ,获得积分10
5分钟前
aaa发布了新的文献求助10
5分钟前
独特的夜阑完成签到 ,获得积分10
5分钟前
等待的问夏完成签到 ,获得积分10
5分钟前
852应助科研通管家采纳,获得10
5分钟前
yxm完成签到 ,获得积分10
5分钟前
5分钟前
乐乐应助布通采纳,获得30
5分钟前
高分求助中
Sustainability in Tides Chemistry 1500
Handbook of the Mammals of the World – Volume 3: Primates 805
拟南芥模式识别受体参与调控抗病蛋白介导的ETI免疫反应的机制研究 550
Gerard de Lairesse : an artist between stage and studio 500
Digging and Dealing in Eighteenth-Century Rome 500
Queer Politics in Times of New Authoritarianisms: Popular Culture in South Asia 500
Manual of Sewer Condition Classification 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3068088
求助须知:如何正确求助?哪些是违规求助? 2722059
关于积分的说明 7475980
捐赠科研通 2369097
什么是DOI,文献DOI怎么找? 1256148
科研通“疑难数据库(出版商)”最低求助积分说明 609472
版权声明 596815