非平衡态热力学
缩放比例
细菌生长
生化工程
增长率
热力学
统计物理学
微生物代谢
熵产生
熵(时间箭头)
生物量(生态学)
产量(工程)
生态学
消散
环境科学
物理
生物
数学
细菌
工程类
遗传学
几何学
作者
Salvatore Calabrese,Arjun Chakrawal,Stefano Manzoni,Philippe Van Cappellen
标识
DOI:10.1073/pnas.2107668118
摘要
Significance Understanding the principles underlying microbial growth is paramount to the cycle of carbon and nutrients in the biosphere, bioremediation technologies, and biochemical engineering, as well as to natural selection and evolution. Yet, fundamental questions remain on the links between mass and energy balances in microbial metabolism and growth. Guided by a nonequilibrium thermodynamics framework, we interpret extensive literature data on microbial growth. The analysis reveals how mass and energy conversion are tightly coupled by scaling laws relating the thermodynamic efficiency to the electron donor uptake rate and the growth yield. Most importantly, these results appear to be universal, in that they apply across microbial species and metabolic pathways, and pave the way for a general thermodynamic theory of microbiological systems.
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