前列腺癌
PRC2
雄激素受体
癌症研究
增强子
EZH2型
谱系（遗传）
生物
细胞生物学
癌症
表观遗传学
遗传学
转录因子
基因
标识
DOI：10.1038/s41556-021-00744-4
摘要
Enhancer of zeste homolog 2 (EZH2) has been shown to promote development of castration-resistant prostate cancer (CRPC) through various mechanisms. A new study now shows that a phosphorylated EZH2 interacts with the androgen receptor (AR) and reprograms AR transcriptional activity to facilitate transition of CRPC into a lineage infidelity state.
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