Novel Cd0.67Mo0.33Se/In2O3 hollow nanotubes were prepared for photocatalytic hydrogen production application. Under visible light irradiation, Cd0.67Mo0.33Se/In2O3 hollow nanotubes showed enhanced photocatalytic performance. And the apparent quantum efficiency of 34.86% was obtained when irradiated with 420 nm monochromatic light. The modification of Cd0.67Mo0.33Se QDs on the surface of In2O3 hollow nanotubes effectively improved the utilization rate of light absorption, increased the separation and migration rate of electrons, inhibited the recombination of photo-generated electron and hole pairs, thus enhancing the photocatalytic activity of water splitting to produce hydrogen. It would be an efficient photocatalyst for hydrogen production application in future.