特立帕肽
医学
甲状旁腺激素
骨矿物
骨质疏松症
内科学
唑来膦酸
N-末端末端肽
内分泌学
股骨颈
泌尿科
骨钙素
碱性磷酸酶
化学
钙
酶
生物化学
作者
Wei Kang,Yimin Qu,Yi Qin Gao,Yong Ma
出处
期刊:JCPSP. Journal of the College of Physicians & Surgeons Pakistan
[College of Physicians and Surgeons Pakistan]
日期:2021-02-01
卷期号:31 (02): 240-242
被引量:4
标识
DOI:10.29271/jcpsp.2021.02.240
摘要
The purpose of this study was to compare the efficacy of teriparatide (parathyroid hormone 1-34) alone and in combination with zoledronic acid (ZA) for the treatment of osteoporosis in postmenopausal women.Ninety-six patients were randomly equally divided into Groups A (n=48) and B (n=48).Group A was given parathyroid hormone 1-34 alone.Group B was treated with parathyroid hormone 1-34 plus ZA.Visual analogue scale (VAS) score, bone mineral density(BMD), serum osteopontin (OPN), and C-terminal cross-linking telopeptide of type I collagen (S-CTX) etc. were compared.After 6 months of treatment, VAS score, serum OPN and S-CTX levels in Group B were significantly lower than those in Group A (p=0.001, p<0.001 and p<0.001, respectively); and BMD values of lumbar vertebrae L 2-4 , femoral neck and total hip bone in Group B were higher than those of Group A (p=0.002, p=0.028 and p<0.001, respectively).In conclusion, parathyroid hormone 1-34 plus ZA is more effective than parathyroid hormone 1-34 alone in treating post postmenopausal osteoporosis.
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