免疫系统
疾病
病因学
医学
神经科学
免疫学
小胶质细胞
补体系统
中枢神经系统
阿尔茨海默病
生物
炎症
病理
作者
Stefan D. Jevtic,Ameet S. Sengar,Michael W. Salter,JoAnne McLaurin
标识
DOI:10.1016/j.arr.2017.08.005
摘要
The immune system is now considered a major factor in Alzheimer Disease (AD). This review seeks to demonstrate how various aspects of the immune system, both in the brain and peripherally, interact to contribute to AD. We highlight classical nervous system immune components, such as complement and microglia, as well as novel aspects of the peripheral immune system that can influence disease, such as monocytes and lymphocytes. By detailing the roles of various immune cells in AD, we summarize an emerging perspective for disease etiology and future therapeutic targets.
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