机械转化
核心
细胞生物学
染色质
细胞质
细胞核
生物
拉明
核板
核运输
核蛋白
转录因子
基因
遗传学
作者
Tyler J. Kirby,Jan Lammerding
标识
DOI:10.1038/s41556-018-0038-y
摘要
The ability of cells to respond to mechanical forces is critical for numerous biological processes. Emerging evidence indicates that external mechanical forces trigger changes in nuclear envelope structure and composition, chromatin organization and gene expression. However, it remains unclear if these processes originate in the nucleus or are downstream of cytoplasmic signals. Here we discuss recent findings that support a direct role of the nucleus in cellular mechanosensing and highlight novel tools to study nuclear mechanotransduction.
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