脂质体
脂类学
脂肪组织
脂质代谢
褐色脂肪组织
脂质信号
细胞生物学
生物
信号转导
产热
内分泌学
生物信息学
生物化学
受体
作者
Sean D. Kodani,Valerie Bussberg,Niven R. Narain,Michael A. Kiebish,Yu‐Hua Tseng
标识
DOI:10.1007/978-1-0716-2087-8_16
摘要
Brown adipose tissue is a thermogenic organ that possesses anti-diabetic and anti-obesogenic potential. There has recently been growing interest on the secretory role of brown adipose tissue in regulating whole-body metabolism. Several signaling lipids, including 12-HEPE and 12,13-diHOME, have been shown to be secreted by brown adipose tissue and have demonstrated roles in regulating whole-body energy metabolism. Lipidomics platforms that broadly characterize the signaling lipidome can deconvolute the underlying biology of the lipid metabolites having a broad systemic impact on physiology. Herein, we describe how to perform and analyze LC-MS/MS signaling lipidomics on mature brown adipocytes.
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