喜树碱
纳米颗粒
材料科学
粒径
纳米技术
细胞毒性
药物输送
毒品携带者
透射电子显微镜
核化学
化学工程
化学
有机化学
体外
生物化学
工程类
作者
Archana Sumohan Pillai,Aleyamma Alexander,Govindaraj Sri Varalakshmi,Varnitha Manikantan,Bose Allben Akash,Israel V.M.V. Enoch
标识
DOI:10.1080/02652048.2022.2094486
摘要
This study aims at tuning the properties of the nanoparticles by incorporating neodymium, exploring the sustained release of drug, and the anticancer activity on breast cancer cells. The crystal characteristics of NdCuS2 nanoparticles are analysed using X-ray diffraction. The morphology and size of the nanoparticles were characterised using Transmission Electron Microscope and particle size analyser. The rate of release of the encapsulated camptothecin and anticancer effects on breast cancer cells are investigated. The nanoparticles are rod-shaped, 132 ± 8 nm long and 27 ± 7 nm wide. The band gap of the nanoparticles is 4.85 eV. The drug encapsulation efficiency is 94.76% (w/w). The drug is released in a sustained manner, over a period of 180 h. The cytotoxicity of the camptothecin-loaded NPs is examined on MDA-MB-231 cells and the IC50 is 4.39 µg mL−1. The NdCuS2 nanoparticles are promising as theranostic agents considering their material characteristics and anticancer activity.
科研通智能强力驱动
Strongly Powered by AbleSci AI