硒
端粒
全国健康与营养检查调查
糖尿病
老化
医学
混淆
2型糖尿病
人口
内科学
生理学
内分泌学
生物
化学
环境卫生
遗传学
DNA
有机化学
作者
Huping Gong,Qian Yu,Dawei Guo,Yuge Wang,Lanzhi Duan,Wenxuan Huang,Jianghua Zhou,Jiang Wang,Pan Huang
标识
DOI:10.1017/s000711452200174x
摘要
Abstract Se is an indispensable trace element for the human body, and telomere length is considered a marker of biological ageing. Previous studies have shown that dietary Se intake is associated with telomere length. However, the relationship between Se intake and telomere length in patients with diabetes has not been well studied. Therefore, this study aimed to investigate the relationship between dietary Se intake and telomere length in patients with diabetes. We extracted 878 participants with diabetes from the National Health and Nutrition Examination Survey database for 1990–2002. Dietary Se intake was assessed using the 24 h dietary recall method, and telomere length was measured using quantitative PCR. Generalised linear models were constructed to assess the relationship between dietary Se intake and telomere length. After controlling for the confounders, 1 μg increase in dietary Se intake in female patients with diabetes, and telomere length increased by 1·84 base pairs (β = 1·84 (95 % CI: 0·15, 3·53)), there was a line relationship between dietary Se intake and telomere length in female patients with diabetes and telomere length increased with increasing dietary Se intake within the range of 0–250 μg. The study demonstrates that dietary Se intake is significantly associated with telomere length only in the female population with diabetes in the USA. However, further prospective studies are required to confirm this finding.
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