Bile Acid Diarrhea Is Associated With Increased Intestinal Permeability Compared With Irritable Bowel Syndrome-Diarrhea

Irritable bowel syndrome (IBS) is associated with diverse peripheral as well as central pathophysiologic mechanisms. 1 Camilleri M. N Engl J Med. 2012; 367: 1626-1635 Google Scholar About 25% of patients with IBS-diarrhea (IBS-D) have bile acid diarrhea (BAD). 2 Valentin N. et al. Gut. 2016; 65: 1951-1959 Google Scholar Intestinal barrier alterations with a subsequent local mucosal immune response to luminal microbial antigens may contribute to the development of IBS. 3 Dunlop S.P. et al. Am J Gastroenterol. 2006; 101: 1288-1294 Google Scholar A summary of intestinal permeability in IBS showed equivocal results in the comparison of permeability in IBS-D and health. 4 Camilleri M. et al. Am J Physiol Gastrointest Liver Physiol. 2019; 317: G17-G39 Google Scholar